Education and Training

2026-now Research Fellow

Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, Shanghai, China

2024-2025 Senior Researcher (Oberassistent)

Institute of Biochemistry, Department of Biology

Eidgenössische Technische Hochschule Zürich (ETH Zürich), Switzerland

Advisor: Frédéric Allain

2018-2024 Postdoctoral Fellow

Institute of Biochemistry, Department of Biology

Eidgenössische Technische Hochschule Zürich (ETH Zürich), Switzerland

Advisor: Frédéric Allain

2017-2018 Postdoctoral Fellow

School of Life Science

University of Science and Technology of China (USTC), Anhui, China

Advisor: Yunyu Shi and Jihui Wu

2016-2017 Research Associate

School of Life Science

University of Science and Technology of China (USTC), Anhui, China

Advisor: Yunyu Shi and Jihui Wu

2009-2016 Ph.D., Structural biology

School of Life Science

University of Science and Technology of China (USTC), Anhui, China

Advisor: Yunyu Shi and Jihui Wu

2005-2009 B.S., Biology

School of Life Science

University of Science and Technology of China (USTC), Anhui, China

Research Experience

2009-2017 Focused on investigating the dynamic structures of non-coding RNAs and their mRNA regulatory mechanisms based on nuclear magnetic resonance (NMR) technology.

2018-2025 Focused on elucidating the molecular mechanisms underlying primer initiation and synthesis by DNA primase via high-field NMR spectroscopy.

2026-Present Focused on the technological innovation of nucleic acid drugs, as well as the development of AI-enhanced novel strategies for NMR structural elucidation.

Honors and Awards

2014 Outstanding Graduate of the University of Science and Technology of China,Hefei, Anhui

2014 Outstanding Graduate of Anhui Province, Hefei, Anhui

2013 Xingye Responsibility Scholarship, University of Science and Technology of China, Hefei, Anhui

2012 Xingye Responsibility Scholarship, University of Science and Technology of China, Hefei, Anhui

2010 Donggang Scholarship, University of Science and Technology of China,Hefei, Anhui

Publications

*corresponding author; #: equal contribution

1.Wu P*, Damberger F, Zehnder J, Schröder N, Senning N, Lipps G, Wiegand T, Allain F*. Structural and Mechanistic Insights into Primer Synthesis Initiation by DNA Primase. Nature Communications. In revision.

2.Wu P#, Zehnder J#, Schroder N#, Blummel P, Salmon L, Damberger F, Lipps G, Allain F*, Wiegand T*. Initial Primer Synthesis of a DNA Primase Monitored by Real-Time NMR Spectroscopy. J Am Chem Soc. 2024 Apr 10;146(14):9583-9596. doi: 10.1021/jacs.3c11836. Epub 2024 Mar 27. PMID: 38538061; PMCID: PMC11009956.

3.Turbant F, Wu P, Wien F*, Arluison V*. The Amyloid Region of Hfq Riboregulator Promotes DsrA:rpoS RNAs Annealing. Biology (Basel). 2021 Sep 12;10(9):900. doi: 10.3390/biology10090900. PMID: 34571778; PMCID: PMC8468756.

4.Lacabanne D, Boudet J, Malär AA, Wu P, Cadalbert R, Salmon L, Allain FH, Meier BH, Wiegand T*. Protein Side-China-DNA Contacts Probed by Fast Magic-Angle Spinning NMR. J Phys Chem B. 2020 Dec 10;124(49):11089-11097. doi: 10.1021/acs.jpcb.0c08150. Epub 2020 Nov 25. PMID: 33238710; PMCID: PMC7734624.

5.Liu X#, Shen S#, Wu P, Li F, Liu X, Wang C, Gong Q, Wu J, Yao X, Zhang H*, Shi Y*. Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res. 2019 Aug 22;47(14):7648-7665. doi: 10.1093/nar/gkz505. PMID: 31251801; PMCID: PMC6698656.

6.Yang Y, Xiang S, Liu X, Pei X, Wu P, Gong Q, Li N, Baldus M, Wang S. Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals. Chem Commun (Camb). 2017 Nov 30;53(96):12886- 12889. doi: 10.1039/c7cc07483b. PMID: 29099144.

7.Wu P, Liu X, Yang L, Sun Y, Gong Q, Wu J*, Shi Y*. The important conformational plasticity of DsrA sRNA for adapting multiple target regulation. Nucleic Acids Res. 2017 Sep 19;45(16):9625-9639. doi: 10.1093/nar/gkx570. PMID: 28934467; PMCID: PMC5766208.

Book Chapters

*corresponding author; #: equal contribution

1.Wu P*, Yang L. sRNA Structural Modeling Based on NMR Data. Methods Mol Biol. 2024;2741:383-397. doi: 10.1007/978-1-0716-3565-0_20. PMID: 38217664.

2.Wu P*, Liu X, Gong Q, Shi Y, Wu J*. Application of NMR Spectroscopy to Determine Small RNA Structure. Methods Mol Biol. 2020;2113:341-353. doi: 10.1007/978-1-0716-0278-2_22. PMID: 32006324.